EOM613 is a peptide-nucleic acid solution created through a chemical process in which ribonucleic acid is combined with short-chain peptides.
EOM613 can produce anti-inflammatory effects in antigen-challenged cells, e.g., diminished secretion of IL-6 and IL-12 (pro-inflammatory cytokines), and a concomitant increased secretion of IL-10 (anti-inflammatory cytokine). The combination of decreased IL-6 and IL-12 and increased IL-10 at the localized sites of antigen activation could mitigate a hyperimmune reaction or “cytokine storm.”
EOM613 can also stimulate a pro-inflammatory response when needed. Normal physiological functions of the cytokines would not be shut off completely elsewhere in the body, as might be expected with an anti-IL-6 or IL-12 antibody.
As noted above, this dual-acting, broad-spectrum approach may overcome a key limitation of many conventional immunomodulators that only reduce the inflammatory state, which may leave a patient more vulnerable to infection. Human cell culture studies suggest that EOM613 may be a dynamically dual-acting immunomodulator that can suppress or stimulate monocytes and macrophages depending on the activation state of those key immune cells.
EOM613 increased secretion of some pro-inflammatory cytokines (IL-6 [A] and GM-CSF [B]), and decreased secretion of others (IL-12 [C] and TNF-ɑ [D]) from LPS-activated adherent monocytes.
EOM613 affects monocyte/macrophage function based on the cellular activation state resulting in either further activation or suppression.
EOM613 promoted a pro-inflammatory response (increased IL-6) in PMA-activated U937 cells, but after those cells were further activated by LPS, EOM613 promoted an anti-inflammatory response by reducing IL-6 secretion.
EOM613 also induced anti-inflammatory effects in PMA- and LPS-activated U937 cells (reduced phagocytosis and increased IL-10 secretion), not shown in this chart.
Watch how EOM613 may work to re-establish natural balance in an immune system that has been confronted by an invading antigen, pathogen, or virus
The legacy of EOM613 began in World War II when its precursor Reticulose was used successfully to treat soldiers with the flu. It was considered a significant treatment advance at the time and has been studied continuously in the pursuit of realizing its full potential as an anti-viral and now in a new formulation as a novel dual-acting, broad-spectrum immunomodulator.